Vaccinopolis Center by Proof of the sum

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2022年3月25日星期五，瓦奇诺波利斯中心正式开放。该疫苗研究中心位于安特卫普大学Drie Eiken校区，用于测试和研究各种病原体疫苗，从而加速对抗新型和已知疾病的进程。安特卫普大学疫苗学家皮埃尔·凡·戴姆表示：“瓦奇诺波利斯中心使我们的国家变得举世瞩目。”

Vaccinopolis opened its doors on Friday 25 March 2022. Vaccines against all kinds of pathogens will be tested and improved in the unique vaccine research center on Campus Drie Eiken, accelerating the fight against new and existing diseases. “With Vaccinopolis we put our country on the map”, says driving force Pierre Van Damme (UAntwerp).

▼项目概览，general view ©Marcel van der Burg

疫苗研发是当今世界面临的最大挑战之一。疫苗学家皮埃尔·凡·戴姆解释道：“新冠病毒鞭策我们趋近事实，但它已经存在了很久。在这期间，气候不断变化，人们之间的距离拉近，同时，旅行越来越频繁，年龄也越来越大，这些都使病毒传播地更加广泛和快速。”安特卫普大学正在与合作伙伴研发管理流行病的创新生态系统，而瓦奇诺波利斯中心则是该生态系统的重要基石，在这里，研究员将测试针对呼吸道合胞病毒、登革热或百日咳等多种传染病的候选疫苗，还将对已知的流感疫苗进行改进研究。

Vaccine development is one of the greatest global challenges today. “Corona has pushed us very hard on the facts,” explains vaccinologist Prof. Pierre Van Damme (UAntwerp). “But the awareness has been there for a long time. The climate is changing, people are living closer together, we are traveling more and more and we are getting older: all evolutions that contribute to a faster and broader spread of viruses.” Together with its partners, the University of Antwerp is developing an innovative ecosystem in pandemic management. Vaccinopolis is an important cornerstone in that ecosystem. Candidate vaccines will be tested at the center against numerous infectious diseases, such as RSV, dengue or whooping cough. It will also be investigated how, for example, the known flu vaccines can be improved.

▼立面局部，facade ©Marcel van der Burg

管理病原体
Administer pathogens

疫苗接种评估中心动态研究的监测工作将在这座全新的综合体里进行，关于此类研究，志愿者会定期进行检查。而瓦奇诺波利斯中心真正与众不同的地方在于其开展人类感染模型研究的能力。凡·戴姆表示：“CHIM即人类感染模型，它意味着首先给测试对象接种疫苗或安慰剂，然后再注射少剂量的病原体。这使研究员能够测试特定的候选疫苗是否发挥作用及其作用机制。而在此之前，欧洲没有这类设施，想要进行这种研究，只能去美国或者英国。”

The ambulatory studies of the Center for the Evaluation of Vaccinations will be monitored in the brand new complex. In such studies, the participating volunteers come for regular check-ups. But what makes Vaccinopolis truly unique is its ability to conduct CHIM studies. Van Damme: “CHIM stands for Controlled Human Infection Model and means that test subjects are first given a vaccine or a placebo and then deliberately administered a reduced dose of the pathogen. This allows the researchers to test whether and how a particular vaccine candidate works. There is no comparable facility on the European mainland. For comparable facilities you have to go to the United States or Great Britain.”

▼项目外观，external view ©Marcel van der Burg

▼西立面，west facade ©Marcel van der Burg

▼立面细部，detail ©Marcel van der Burg

全面隔离
Full quarantine

瓦奇诺波利斯中心中心设有三十张床位。在某些研究中，测试对象会被隔离数周。这样做的原因，一方面是出于安全的考虑，即不能让病原体在社会中广泛传播；另一方面是因为这样可以对志愿者进行密切监测。临床试验团队负责人伊尔斯·德·科斯特教授表示：“这样一来，我们每天都可以从测试对象身上采集样本，并且基于这些样本，预测出特定人群对特定疫苗的反应。每项研究都事先得到独立伦理委员会的批准，而且他们要求研究只针对已有治疗方法的病原体。”

Vaccinopolis has thirty beds. In some studies, the test subjects will remain in full quarantine for several weeks. On the one hand, this is done for safety reasons: the pathogens must of course not be given free rein in society. On the other hand, the volunteers can be closely monitored. “That way you can also take daily samples from the test subjects,” says Dr. Ilse De Coster, head of the clinical trial team. “Based on those characteristics, we can eventually try to predict how specific groups of people will respond to a particular vaccine. Each study is pre-approved by an independent ethics committee and only studies are conducted with pathogens for which there is already a treatment.”

▼公共大厅，public hall ©Marcel van der Burg

▼二层概览，overall of first floor space ©Marcel van der Burg

▼观察室，observation room ©Marcel van der Burg

▼空间细节，details ©Marcel van der Burg

▼公共区域，communal space ©Marcel van der Burg

▼隔离走廊，isolation corridor ©Marcel van der Burg

▼隔离房间，isolation room ©Marcel van der Burg

▼浴室，bathroom ©Marcel van der Burg

不同安全级别
Different security levels

该建筑在破纪录的时间内完工：整个过程持续十四个月。Proof of the sum事务所的建筑师罗伊派佩解释道：“通常，这样的项目落地需要四到五年的时间，但此次情况特殊，因为新冠病毒迅速而意外地袭击了人类。”设计师和施工方组合成IMM/Unity联合体，共同完成了该项目。其中，整体设计由Proof of the sum、Exilab、Abstract Architecten、burO Groen和Establis负责，项目落地则由Jansen Building Group、Jansen Cleanrooms和Cordeel完成，此外，Imtech Belgium将与Jansen Cleanrooms一起负责未来15年的维护工作。该项目在短期内完成，又没有对生物安全领域造成危害，这是因为整个建筑采用严格的净化程序，所有排气也会经由专用过滤器过滤。

The building was completed in record time: the entire process was completed in fourteen months. “Usually, the realization of such a project takes four to five years”, explains architect Roy Pype (Proof of the sum). “But the circumstances were exceptional: COVID-19 proves that viruses can strike quickly and unexpectedly.” Under the consortium name ‘IMM/Unity’, designers and builders have integrally designed and realized the project. Proof of the sum, Exilab, Abstract Architecten, burO Groen and Establis were responsible for the integral design. The realization was in the hands of Jansen Building Group, Jansen Cleanrooms and Cordeel. Imtech Belgium, together with Jansen Cleanrooms, will be responsible for maintenance for fifteen years. The work was done quickly, but nothing was left to chance in the field of biosecurity. Strict decontamination procedures apply throughout the complex and special filters filter all outgoing air.

▼研究室，research room ©Marcel van der Burg

▼设备间，equipment room ©Marcel van der Burg

安特卫普大学 x 布鲁塞尔自由大学
UAntwerp x ULB

比利时联邦政府向瓦奇诺波利斯中心投资了1300万欧元（合人民币9332万元），私人合作伙伴也为完成该项目进行了投资。瓦奇诺波利斯中心与布鲁塞尔自由大学有着密切合作：布鲁塞尔自由大学在人类疫苗免疫学领域成就显赫，而且从现在开始，这项工作将在高质量的免疫学实验室内进行。

The Belgian federal government invested 13 million euros in Vaccinopolis. Private partners also invested in the realization of the project. There is close cooperation with the ULB: the Brussels university is very successful in the field of human vaccine immunology and from now on does this from a high-quality immunological laboratory.

▼一层平面图，ground floor plan ©Proof of the sum

▼二层平面图，first floor plan ©Proof of the sum

▼三层平面图，second floor plan ©Proof of the sum

▼四层平面图，third floor plan ©Proof of the sum

▼五层平面图，forth floor plan ©Proof of the sum

▼北立面图，north elevation ©Proof of the sum

▼南立面图，south elevation ©Proof of the sum

▼东立面图&西立面图，east elevation & west elevation ©Proof of the sum

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